Retatrutide, an investigational triple agonist of GIP, GLP-1, and glucagon receptors, may be useful for the treatment of painful knee osteoarthritis in persons with obesity. In two phase 3 trials, ...

For patients with moderate aortic stenosis, current guidelines recommend clinical surveillance with echocardiographic assessment every 1 or 2 years. Whether transcatheter aortic-valve replacement ...

Obesity is the most common chronic disease in the world.1 Even more devastating are its sequelae, which range from sleep apnea and osteoarthritis to an increased risk of cardiovascular disorders, ...

Health worker burnout, exacerbated by Covid-19, is not only about long hours. It’s about the fundamental disconnect between health workers and the mission to serve that motivates them.

Although international guidelines recommend intrauterine insemination (IUI) with ovarian stimulation as first-line treatment for unexplained infertility, evidence from comparisons of this method with ...

When patients, or the parents of patients, become heavily invested in searching for someone to blame for an illness, it’s useful to ask what the search is doing for them. Its accuracy is rarely ...

The U.S. health care system still can’t identify medical harm as it occurs. But it’s now possible to develop systems that correct their own deficiencies and make improvements that matter to patients.

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 20).

Multiple myeloma has undergone a therapeutic revolution at a pace nearly unmatched in oncology. Yet amid these advances, a key assumption in multiple myeloma therapy persists: more and longer ...

When we become obsessed with finding the right answer, at the risk of oversimplifying the richly iterative and evolutionary nature of clinical reasoning, the result is the very antithesis of ...

In adults with symptomatic severe aortic stenosis, aortic-valve replacement (AVR) relieves symptoms and improves survival. 1-3 Over the past 20 years, more information about the progression of aortic ...